amministrazione@cert.unimol.it

+39 0874 40 41

Dott. Antonio Carriero

Informazioni accademiche
  • SSD: MED/16
  • Tutor: Prof. Ennio Lubrano Di Scorpaniello

Attività di ricerca
Anticorpi anti-DFS70 nelle artriti infiammatorie: impatto della terapia con anti-TNFalpha.

Introduzione
Gli anti-DFS70, anti-dense fine speckled of 70kD, sono stati ipotizzati potenziali marker di esclusione di malattie sistemiche autoimmuni reumatologiche. Vi sono limitati studi in Artrite Reumatoide e per le Spondiloartriti per cui il loro significato clinico/biologico è ancora poco chiaro; in particolare è sconosciuta l’influenza di fattori demografici, genetici o terapeutici sullo sviluppo di questi anticorpi. È nota invece la comparsa di ANA durante la terapia con anti-TNFalpha ma non vi sono dati sull’eventuale sviluppo di anti-DFS70.

Obiettivi
  • Studiare la prevalenza degli anti-DFS70 in Artrite Reumatoide e Spondiloartriti.
  • Studiare i fattori scatenanti lo sviluppo degli anti-DFS70.
  • Rispondere alla domanda sull’eventuale ruolo protettivo degli anti-DFS70 e correlare i riscontri sierologici alle variabili cliniche.

Materiali e metodi
Sieri di 100 pazienti con Artrite Reumatoide e 100 con Spondiloartriti saranno sottoposti ad ANA-test con IFI ed immunoblotting per la ricerca degli anti-DFS70.

Risultati e conclusioni
  • Chiarire il valore degli anti-DFS70 nell’algoritmo diagnostico delle artriti infiammatorie croniche.
  • Comprendere l’effetto della terapia anti-TNFalpha nell’eventuale sviluppo degli anti-DFS70
  • Eventuale futuro sviluppo di studi clinici per comprendere il valore predittivo degli anti-DFS70 e correlarne il titolo con attività di malattia, danno radiologico o ulteriori variabili.
Pubblicazioni in extenso su riviste con impact factor
  • D'Angelo S., Carriero A., Gilio M., Ursini F., Leccese P., & Palazzi C., "Safety of treatment options for spondyloarthritis: a narrative review". Expert Opin Drug Saf. 2018 May;17(5):475-486.
  • Corrado A., Correale M., Mansueto N., Monaco I., Carriero A., Mele A., Colia R., Di Biase M., & Cantatore F. P., "Nailfold capillaroscopic changes in patients with idiopathic pulmonary arterial hypertension and systemic sclerosis-related pulmonary arterial hypertension". Microvasc Res. 2017 Nov;114:46-51. doi: 10.1016/j.mvr.2017.06.005.
Pubblicazioni in forma di abstracts su riviste indicizzate
  • Carriero A., Abignano G., Hutchinson M., Ballard K., Eng S., Emery P., Buch M., & Del Galdo F., "Serum interferon score predicts clinical outcome at 12 months in diffuse cutaneous systemic sclerosis as measured by global ranked composite score (GRCS) and composite response index in ssc (CRISS)". Annals of the Rheumatic Diseases 2019;78:A839.
  • Abignano A., Carriero A., Eng S., & Del Galdo F., "Modified ACR composite response index in systemic sclerosis score shows sensitivity and external validation to measure magnitude of response at 12 months in diffuse cutaneous systemic sclerosis". Annals of the Rheumatic Diseases 2019;78:A1207.
  • Abignano G., Mennillo G. A., Carriero A., Esposito C., Padula A., Khanna D., & D’Angelo S., "University of California Los Angeles scleroderma clinical trials consortium gastrointestinal tract 2.0 reflux-scale associates with impaired esophageal scintigraphy findings in systemic sclerosis". Annals of the Rheumatic Diseases 2019;78:A836.
  • Carbone A., Esposito A., Mercuro O., Carriero A., Picerno V., Padula M. C., Padula A., Pafundi V., & D’Angelo S., "Anti-dfs70 autoantibodies induced by anti-tnf therapy in rheumatoid arthritis and spondyloarthritis patient". Annals of the Rheumatic Diseases 2019;78:A1420.
  • Esposito C., Carbone T., Carriero A., Picerno V., Padula M. C., Padula A., Pafundi V., & D’Angelo S., "The spectrum of myositis antibodies: clinical correlation and prevalence of anti-dfs70". Annals of the Rheumatic Diseases 2019;78:A1426.
  • Carriero A., Abignano G., Hutchinson M., Ballard K., Eng S., Emery P., Buch M., & Del Galdo F., "Serum interferon score predicts clinical outcome at 12 months in diffuse cutaneous systemic sclerosis as measured by global ranked composite score (GRCS) and composite response index in ssc (CRISS)". Rheumatology, Volume 58, Issue Supplement_3, April 2019, kez107.047.
  • Corinaldesi C., El-Sherbiny Y. M., Migneco G., Ross R. L., Carriero A., McKimmie C, & Del Galdo F., "A monoclonal antibody against BDCA-2 inhibits TLR-induced activation of human pDC in vitro and in vivo: a novel therapeutic target for systemic sclerosis", Rheumatology, Volume 58, Issue Supplement_3, April 2019, kez107.044.
  • Corrado A., Correale M., Mansueto N., Mele A., Carriero A., Colia R., Di Biase M., & Cantatore F. P., "Nailfold capillaroscopic changes in patients with idiopathic and systemic sclerosis-related pulmonary arterial hypertension". Annals of the Rheumatic Diseases 2017;76:895.
  • Colia R., Corrado A., Maruotti N., Carriero A., d'Onofrio F., & Cantatore F. P., "Effects of different anti tnf alpha treatments on lipid and carbohydrate metabolism in patients with rheumatoid arthritis and psoriatic arthritis". Annals of the Rheumatic Diseases 2016;75:594-595.
  • Carriero A., Corrado A., Di Bello S., Tiso A., D'Onofrio F., & Cantatore F. P., "Familial Behçet's Disease: a report of 2 cases from an Italian Behçet Family". 17th International conference on Behçet's disease – Matera, 2016: Poster: P102. Clin Exp Rheumatol. 2016 Sep-Oct;34(6 Suppl 102):S181.
  • Di Bello S., Corrado A., Di Bello V., Carriero A., D'Onofrio F., & Cantatore F. P., "A case of Behçet's disease presenting with deep venous thrombosis". 17th International conference on Behçet's disease – Matera, 2016: Poster: P123. Clin Exp Rheumatol. 2016 Sep-Oct;34(6 Suppl 102):S181.
  • D'Angelo S., Leccese P., Padula A., Nigro A., Gilio M., Carriero A., Palazzi C., & Olivieri I., "FRI0254 Predictive Factors for the Response to Infliximab Therapy in Patients with Behçet's Disease". Annals of the Rheumatic Diseases 2015;74:516-517.
  • D'Angelo S., Leccese P., Padula A., Nigro A., Gilio M., Carriero A., Palazzi C., & Olivieri I., "Predictive Factors for the Response to Infliximab Therapy in Patients with Behçet’s Disease". ACR/ARHP Boston 2014. Arthritis Rheumatol. 2014 Oct;66 Suppl 10:S1-S1402.
Lavori scientifici presentati a congressi/convegni nazionali ed internazionali
  • Carriero A., Abignano G., Hutchinson M., Ballard K., Eng S., Emery P., Buch M., & Del Galdo F., "Serum interferon score predicts clinical outcome at 12 months in diffuse cutaneous systemic sclerosis as measured by global ranked composite score (GRCS) and composite response index in ssc (CRISS)". Oral communication at 2019 ACR/ARP Annual Meeting 2019, Atlanta, GA, 13/11/2019.
  • Carriero A., Picerno V., Padula A., & D’Angelo S., "Pilot study of ultrasound-guided corticosteroid injection for dactylitis in psoriatic arthritis". Accepted oral communication at ISIAT (International Symposium Intra Articular Treatment) conference, Lisbon 03/10/2019 – 05/10/2019.
  • Carriero A., Abignano G., Hutchinson M., Ballard K., Eng S., Emery P., Buch M., & Del Galdo F., "Serum interferon score predicts clinical outcome at 12 months in diffuse cutaneous systemic sclerosis as measured by global ranked composite score (GRCS) and composite response index in ssc (CRISS)". Accepted poster at EULAR Congress 2019, Madrid 12/06/2019 – 15/06/2019
  • Abignano A., Carriero A., Eng S., & Del Galdo F., "Modified ACR composite response index in systemic sclerosis score shows sensitivity and external validation to measure magnitude of response at 12 months in diffuse cutaneous systemic sclerosis". Accepted poster at EULAR Congress 2019, Madrid 12/06/2019 – 15/06/2019
  • Abignano G., Mennillo G. A., Carriero A., Esposito C., Padula A., Khanna D., & D’Angelo S., "University of California Los Angeles scleroderma clinical trials consortium gastrointestinal tract 2.0 reflux-scale associates with impaired esophageal scintigraphy findings in systemic sclerosis". Accepted poster at EULAR Congress 2019, Madrid 12/06/2019 – 15/06/2019
  • Carbone A., Esposito A., Mercuro O., Carriero A., Picerno V., Padula M. C., Padula A., Pafundi V., & D’Angelo S., "Anti-dfs70 autoantibodies induced by anti-tnf therapy in rheumatoid arthritis and spondyloarthritis patient". Accepted poster at EULAR Congress 2019, Madrid 12/06/2019 – 15/06/2019
  • Esposito C., Carbone T., Carriero A., Picerno V., Padula M. C., Padula A., Pafundi V., & D’Angelo S., "The spectrum of myositis antibodies: clinical correlation and prevalence of anti-dfs70". Accepted poster at EULAR Congress 2019, Madrid 12/06/2019 – 15/06/2019
  • Carriero A., Abignano G., Hutchinson M., Ballard K., Eng S., Emery P., Buch M. H., & Del Galdo F., "Serum interferon score predicts clinical outcome at 12 months in diffuse Systemic Sclerosis as measured by Global Ranked Composite Score (GRCS) and Composite Response Index in SSc (CRISS)". Accepted poster at British Society for Rheumatology Annual Conference 2019 at Birmingham ICC 30th April – 2nd May.
  • Corinaldesi C., El-Sherbiny Y. M., Migneco G., Ross R. L., Carriero A., McKimmie C., & Del Galdo F., "A monoclonal antibody against BDCA-2 inhibits TLR-induced activation of human pDC in vitro and in vivo: a novel therapeutic target for systemic sclerosis". Accepted poster at British Society for Rheumatology Annual Conference 2019 at Birmingham ICC 30th April – 2nd May.
  • D'Angelo S., Leccese P., Padula A., Nigro A., Gilio M., Carriero A., Palazzi C., & Olivieri I. "Predictive Factors for the Response to Infliximab Therapy in Patients with Behçet’s Disease". ACR/ARHP Boston 2014.
Poster
  • Corrado A., Correale M., Mansueto N., Mele A., Carriero A., Colia R., Di Biase M., & Cantatore F. P., "Nailfold capillaroscopic changes in patients with idiopathic and systemic sclerosis-related pulmonary arterial hypertension". EULAR Madrid 2017: EULAR17-5091 (Poster Presentation).
  • Colia R., Corrado A., Maruotti N., Carriero A., D'Onofrio F., & Cantatore F. P., "Effects of different anti tnf alpha treatments on lipid and carbohydrate metabolism in patients with rheumatoid arthritis and psoriatic arthritis". EULAR London 2016: EULAR16-4675 (Poster Presentations).
  • Carriero A., Corrado A., Di Bello S., Tiso A., D'Onofrio F., & Cantatore F. P., "Familial Behçet's Disease: a report of 2 cases from an Italian Behçet Family". 17th International conference on Behçet's disease – Matera, 2016: Poster: P102.
  • Di Bello S., Corrado A., Di Bello V., Carriero A., D'Onofrio F., & Cantatore F. P., "A case of Behçet's disease presenting with deep venous thrombosis". 17th International conference on Behçet's disease – Matera, 2016: Poster: P123.
  • Carriero A., Corrado A., Bellantuono G., Tiso A., & Cantatore F. P., "Risoluzione di un’alveolite emorragica in paziente affetto da granulomatosi con poliangioite". SIR puglia 2016 Taranto. Poster.
  • D'Angelo S., Leccese P., Padula A., Nigro A., Gilio M., Carriero A., Palazzi C., & Olivieri I., "Predictive factors for the response to infliximab therapy in patients with behçet's disease". EULAR Rome 2015: EULAR15-3751 (Poster Presentation).
  • D'Angelo S., Leccese P., Padula A., Nigro A., Gilio M., Carriero A., Palazzi C., & Olivieri I., "Predictive factors for the response to infliximab therapy in patients with behçet's disease". 15th International conference on Behçet's disease – Paris, 2014. Poster.
  • D'Angelo S., Leccese P., Padula A., Nigro A., Gilio M., Carriero A., Palazzi C., & Olivieri I., "Long term therapy with Infliximab in 76 Italian patients with Behcet’s Disease". 15th International conference on Behçet's disease – Paris, 2014. Poster.
Comunicazioni orali a congressi nazionali/internazionali
  • Carriero A., Picerno V., Padula A., & D’Angelo S., "Pilot study of ultrasound-guided corticosteroid injection for dactylitis in psoriatic arthritis". Accepted oral communication at ISIAT (International Symposium Intra Articular Treatment) conference, Lisbon 03/10/2019 – 05/10/2019
  • Carriero A., "Alveolite emorragica in corso di Micropoliangioite con Granulomatosi", congresso Focus on Rheumatologia. Foggia. 28/01/2017
  • Carriero A., "Meet the expert. Expert opinion on Ability I, Adept and Atlas studies". Rome 10/04/2014 and 14/04/2014
  • Carriero A., Abignano G., Hutchinson M., Ballard K., Eng S., Emery P., Buch M., & Del Galdo F., "Serum interferon score predicts clinical outcome at 12 months in diffuse cutaneous systemic sclerosis as measured by global ranked composite score (GRCS) and composite response index in ssc (CRISS)". Accepted oral communication at 2019 ACR/ARP Annual Meeting 2019, Atlanta, GA, 08/11/2019 – 13/11/2019
Libri
  • Manuale di Reumatologia. Quarta edizione – Concorso Nazionale SSM 2018. Accademia It. Medici Spec. ISBN 978-88-3341-001-2.
  • Manuale di Reumatologia. Quinta edizione – Concorso Nazionale SSM 2019. Accademia It. Medici Spec. ISBN 978-88-3341-029-6.
  • Manuale di Reumatologia. Sesta edizione – Concorso Nazionale SSM 2020. Accademia It. Medici Spec. In press.