Gentile Fabrizio

RESEARCH TOPICS:

The activity of the research group focuses on the effects of post-translational modifications on the immunopathogenic properties of protein autoantigens, both in vitro and in vivo. In particular, the following subjects are under study:

1. a) the influence of the chondroitin 6-sulfate oligosaccharide unit on the immunopathogenic properties of human thyroglobulin, with regard both to its ability to induce experimental autoimmune thyroiditis in a murine model and to the clinico-pathological correlations in human samples from fine needle cytology of thyroid;
2. b) the formation of adducts of the products of lipid peroxidation with the cell proteome in the course of oxidative stress, in continuous lines of myeloid human cells;
3. c) nitration of human plasma fibrinogen as a possible cause of acquired dysfibrinogenemia in chronic inflammatory and autoimmune diseases, such as: systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis, rheumatoid arthritis, Behçet’s disease.

The research group is composed by:

–   prof. Fabrizio Gentile, full professor of General Pathology – MED/04;

–   dott. Alessia Arcaro, research doctor; lecturer of General Pathology for the Bachelor degree in Nursing; teaching assistant of General Pathology for the Masterly degree in Biology and of Immunology and Fundamentals of Pathology for the Masterly degree in Biological Sciences;

• dott. Giovanni Paolo Cetrangolo, research doctor; teaching assistant in Phisiology and Fundamentals of Immunology for the Bachelor degree in Biology.In addition, several students have joined and still join the research group temporarily, in order to prepare their doctoral theses for the Masterly degree in Medicine and Surgery and the Masterly degree in Biology.

COLLABORATION:

The research group collaborates stably with:

Prof. Giuseppina Barrera, Department of Clinical and Biological Sciences, University of Turin, Italy;

Dr. Paul R. J. Ames, CEDOC, NOVA Medical School, Universida de NOVA de Lisboa, Portugal, and Department of Haematology, Dumfries Royal Infirmary, Scotland, UK;

Dr. Alessia Arcaro (Teaching Assistant of General Pathology);

Dr. Giovanni Paolo Cetrangolo (Teaching Assistant in Physiology and Fundamentals of Immunology).

OrcID

Fabrizio Gentile: orcid.org/0000-0002-6704-3115

Alessia Arcaro: orcid.org/0000-0002-5924-3694

Giovanni Paolo Cetrangolo: orcid.org/0000-0002-3151-9900